308 Incremental improvements after switching from dupilumab (DUPI) to upadacitinib (UPA) in the Heads Up open-label extension (OLE) study
نویسندگان
چکیده
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous morphology and intense itch. Heads Up was phase 3b, randomized, double-blind, double-dummy clinical trial comparing the efficacy safety of DUPI vs UPA in adults with moderate-to-severe AD over 24 weeks; OLE, all patients received 30 mg orally once daily for an additional 52 weeks. This analysis incremental changes Eczema Area Severity Index (EASI) Worst Pruritus Numerical Rating Scale (WP-NRS) scores during OLE who switched from to after weeks treatment. Among did not achieve ≥75% improvement EASI (EASI 75) DUPI, 75.0% 87.5% achieved 75 4 16 weeks, respectively, while 0% 2.0% maintain this response UPA. Similar results were observed 90. WP-NRS ≥4 at baseline 56.6% 57.7% 3.7% 8.8% Most suboptimal <75 <4) experienced greater clearance itch reduction switching These are first observations reported receiving following treatment DUPI.
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.05.316